Orphenadrine adverse effects include dryness of mouth with difficulty in swallowing and talking, thirst, reduced bronchial secretions, dilation of the pupils with loss of accommodation and photophobia, flushing and dryness of skin, transient bradycardia followed by tachycardia with palpitation and arrhythmias and difficulty in micturition as well as reduction in the tone and motility of the gastrointestinal tract leading to constipation.
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