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Symptoms: Renal disorders such as acute renal failure and eighth cranial nerve impairment such as hearing loss may occur.
Measures: Supportive care is advised, with maintenance of glomerular filtration. This drug is poorly removed by dialysis and hemofiltration and hemoperfusion with polysurfone resin have been reported to result in increased clearance of this drug. The median lethal intravenous dose is 319 mg/kg in rats and 400 mg/kg in mice.
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