Mersa IV 500/Mersa IV 1000 Caution For Usage

Special Precaution for Disposal and Other Handling: For single use. Discard any unused contents.
500 mg: Preparation of Solution: At the time of use, add 10 mL of Sterile Water for Injection to a 500 mg vial of Vancomycin (Mersa IV 500) Lyophilized Powder for Injection (IV Infusion). Vials reconstituted in this manner will give a solution of 50 mg/mL.
1 g: Preparation of Solution: At the time of use, add 20 mL of Sterile Water for Injection to a 1 g vial of Vancomycin (Mersa IV 1000) Lyophilized Powder for Injection (IV Infusion).
Further dilution is required depending on method of administration: Intermittent infusion (the preferred method of administration): Reconstituted solutions containing 500 mg Vancomycin (Mersa IV 500) must be diluted with at least 100 mL diluent.
Reconstituted solutions containing 1 g Vancomycin (Mersa IV 1000) must be diluted with at least 200 mL diluent.
Sodium Chloride 0.9% Intravenous Infusion or 5% Dextrose Intravenous Infusion are suitable diluents. The desired dose should be administered by intravenous infusion over a period of at least 60 minutes. If administered over a shorter period of time or in higher concentrations, there is a possibility of inducing marked hypotension in addition to thrombophlebitis.
Rapid administration may also produce flushing and a transient rash over the neck ad shoulders.
Continuous infusion (should only be used when intermittent infusion not feasible): 1 g or 2 g of Vancomycin (Mersa IV 500 & 1000) may be added to a sufficiently large volume of Sodium Chloride 0.9% Intravenous Infusion or 5% Dextrose Intravenous Infusion to permit the desired dose to be infused over twenty-four hours.