Life-threatening infections due to susceptible gm +ve organisms which cannot be treated by penicillins & cephalosporins. Severe Staph infections in patients who cannot receive or who have failed to respond to the penicillins & cephalosporins or who have infections w/ Staph that are resistant to other antibiotics. Endocarditis & prophylaxis against endocarditis in patients at risk from dental or surgical procedures. Osteomyelitis, pneumonia, septicemia & soft tissue infections.
IV infusionAdult 500 mg every 6 hr or 1 g every 12 hr over 60 min. Childn>1 mth 10 mg/kg per dose every 6 hr over 60 min. Infant Initially 15 mg/kg, followed by 10 mg/kg every 12 hr for neonates in 1st wk of life & thereafter every 8 hr up to 1 mth over 60 min.
Hearing loss. Avoid long-term therapy. Colitis, severe diarrhea. Thrombophlebitis may occur w/ high conc IV administration. Avoid rapid infusion as may cause hypotension. Do not mix w/ drug w/ alkaline soln & w/ β-lactam antibiotics. Impaired vestibular organ or cochlea. Renal impairment. Pregnancy & lactation. Elderly. Premature infant, neonate & toddler.
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