Adult Moderate to severe pneumonia due to S. pneumoniae, P. aeruginosa, K. pneumoniae, or Enterobacter spp 1-2 g IV every 12 hr for 10 days.
Empiric therapy for febrile neutropenic patients 2 g IV every 8 hr for 7 days or until resolution of neutropenia.
Mild to moderate uncomplicated or complicated UTI including pyelonephritis due to E. coli, K. pneumoniae, or P. mirabilis including cases associated w/ concurrent bacteremia 0.5-1 g IV or IM every 12 hr for 7-10 days.
Severe uncomplicated or complicated UTI including pyelonephritis due to E. coli or K. pneumoniae including cases associated w/ concurrent bacteremia 2 g IV every 12 hr for 10 days.
Moderate to severe uncomplicated skin & skin structure infections due to S. aureus or S. pyogenes 2 g IV every 12 hr for 10 days.
Complicated intra-abdominal infections (used in combination w/ metronidazole) caused by E. coli, viridans group strep, P. aeruginosa, K. pneumoniae, Enterobacter spp or B. fragilis 2 g IV every 12 hr for 7-10 days.
Renal impairment CrCl >60 mL/min 500 mg, 1 g or 2 g every 12 hr,
30-60 mL/min 500 mg, 1 g, or 2 g every 24 hr,
11-29 mL/min 500 mg, 1 g or 2 g every 24 hr,
<11 mL/min 250 mg, 500 mg or 1 g every 24 hr.
CAPD 500 mg, 1 g, or 2 g every 48 hr.
Hemodialysis 1 g on day 1, then 500 mg every 24 hr thereafter or 1 g every 24 hr.
Ped patient (2 mth-16 yr) up to 40 kg Uncomplicated & complicated UTI including pyelonephritis, uncomplicated skin & skin structure infections, & pneumonia 50 mg/kg/dose every 12 hr. 50 mg/kg/dose every 8 hr for febrile neutropenic patients.
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