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Symptoms: The problems of overdose are seldom occurred but when it occurs, gastrointestinal symptoms (stomach & abdominal pain, diarrhea, vomiting, etc.), imbalance of body fluids and electrolytes, and in some cases, rashes, hyperactivity disease, drowsiness, might be observed.
In case of amoxicillin overdose, it has been rarely reported that interstitial nephritis was observed due to oliguric renal failure. The symptoms of renal failure has been reversibly recovered when the administration of the drug was stopped. Patients with renal failure have maintained high blood concentrations of drug because of decreased renal clearance rates of amoxicillin and potassium clavulanate.
In case of penicillin overdose, epileptic convulsion might occur. Patients receiving penicillin have often shown anaphylactic shock, although it is not a symptom due to poisoning. It is rare but acute and can be fatal. It might be generally appeared within 30 minutes of drug administration. All possible treatments should be performed immediately to normalize the blood circulation.
Other allergic reactions such as skin reactions, bleeding, and pancytopenia can be occurred.
Treatments: Stop the medication immediately if it occurred and treatments should be performed depending on the symptoms while balancing the water-electrolyte equilibrium. This drug can be eliminated by hemodialysis. If the overdose is very recent and there is no contraindication, an attempt at emesis or other means of removal of drug from the stomach may be performed (in case of oral preparations).
In the presence of convulsion due to overdose, diazepam is used to tranquilize the condition.
