Lox Drug Interactions

It is not desirable to use with probenecid at the same time. Probenecid decreases the renal tubular secretion of amoxicillin and thus concurrent use with Co-amoxiclav may result in increased and prolonged blood levels of amoxicillin regardless of clavulanic acid.
Concomitant use of allopurinol and ampicillin can increase the likelihood of allergic skin reactions (rashes) in patients when compared in those receiving ampicillin only. However, it is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients.
Co-administration of disulfiram cannot be recommended.
Prolongation of bleeding time and prothrombin time has been reported in some patients receiving this drug. Thus, more cautious administration of this drug is recommended in case of patients under the anticoagulant therapy.
Patients should aware that it can reduce the efficacy of oral contraceptive by influencing the intestinal flora.
Simultaneous administration of acetyl salicylic acid, phenylbutazone, and large amount of anti-inflammatory agent with penicillin increases the blood concentration.
Co-administration of oral chemotherapy antibiotics including tetracyclines, macrolides, sulfonamides, and chloramphenicols develops antagonism (counteraction).
When used with sulfasalazine at the same time, it decreased the plasma concentration of sulfasalazine.
Amoxicillin decreases the renal clearance rate of methotrexate.
Changes of INR (international normalized ratio): The increased anticoagulant activity has been reported in patients who received anticoagulant with antibiotics including this drug. Infectious diseases (and accompanied by inflammation), age, and general condition of a patient can become risk factors. Although the interaction between this drug and warfarin has not been proved through clinical studies, INR monitoring should be performed and the dose of oral anticoagulants should be properly controlled if necessary. Some kinds of antibiotics, particularly fluoroquinolones, macrolides, cyclines, co-trimoxazole, and some cephalosporins heavily interact with anticoagulants.
The absorption of cardiac glycosides (including digoxin) can be increased in some patients because the use of antibiotics affects the intestinal flora.
Drug Laboratory Interactions: This drug is largely excreted in the urine. High urine concentrations of ampicillin may result in false-positive reactions when testing for the presence of glucose in urine using Clinitest, Benedict's Solution or Fehling's Solution. Thus, it is not desirable to perform these tests while a patient is receiving this drug. This drug does not influence tes-tape test.
It has been observed that the plasma concentrations of total conjugated estriol, estriol glucoronide, conjugated estrone, and estradiol were temporarily decreased when ampicillin was administered to pregnant women. This result was also observed when amoxicillin and this drug were administered.
It can be influenced in the urobilinogen test.
Clavulanic acid tends to be absorbed on the membrane surface of erythrocytes. If an antibody for the drug exists, the result of the Coombs' test can be positive.
It should be careful for the following tendency when using high concentration of amoxicillin: It interferes with the decision of total protein ratio of serum due to color reaction.