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Hypertension: For the treatment of hypertension; may be used alone or in combination with other antihypertensives, including diuretics.
Hypertensive Patients with Left Ventricular Hypertrophy: Decreases the risk of cardiovascular morbidity and mortality as measured by the combined incidence of cardiovascular death, stroke, and myocardial infarction in hypertensive patients with left ventricular hypertrophy.
Heart Failure: Heart failure in patients who cannot tolerate an ACE inhibitor.
Nephropathy in Type 2 Diabetic Patients: For the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio ≥300 mg/g) in patients with type 2 diabetes and a history of hypertension.
Decreases the progression of nephropathy as measured by the occurrence of doubling serum creatinine, end stage renal disease (need for dialysis or renal transplantation), or death; Reduces proteinuria.
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