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No overdosage has been reported with adapalene and clindamycin in human beings.
Adapalene Microspheres + Clindamycin Phosphate Gel is intended for topical use only. If the medication is applied excessively, no more rapid or better results will be obtained but marked redness, peeling or discomfort may occur.
The acute oral toxicity of Adapalene in mice and rats is greater than 10 mL/kg. Chronic ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of Vitamin A.
Clindamycin may be absorbed to produce systemic effects.
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