Some adverse effects such as erythema, scaling, dryness, pruritus and burning occur in 10-40% of patients. Pruritus or burning immediately after application also occurs frequently. In approximately 1% or less of patients, skin irritation, burning/stinging, erythema. sunburn and acne flares have also been reported. These are most commonly seen during the first month of therapy and decrease in frequency and severity thereafter. All adverse effects with the use of Adapalene and Clindamycin during clinical trials were reversible after discontinuation of therapy.