Ticagrelor is tolerated in single doses up to 900 mg. There is currently no known treatment to reverse the effects of Ticagrelor, and ticagrelor is not expected to be dialysable. Treatment of overdose should follow local standard medical practice. Bleeding is the expected pharmacologic effect of overdosing. If bleeding occurs, appropriate supportive measures should be taken. Other effects of overdose may include gastrointestinal effects (nausea, vomiting, diarrhea) or ventricular pauses. Monitor the ECG.