Flumig Use In Pregnancy & Lactation

Pregnancy/Reproduction: Fertility: In studies in male and female Wistar rats at doses of 0 and approximately 10, 40, and 160 mg/kg given for 60 days pre-mating in the males or 14 days pre-mating and 21 days of gestation in the females, treated animals were mated with non-treated animals. In treated females at the highest dose, there were no pregnancies and a large number of deaths; at the 40 mg/kg dose, there was decreased weight gain during pregnancy, decreased rate of pregnancy, increase in the number of resorbed fetuses, decreased litter size, and decreased weight of pups at birth. In non-treated females mated with treated males, a slight increase in resorption was seen only at the highest dose.
Pregnancy: Studies in humans have not been done.
There was a slight increase in resorptions and decrease in number of live fetuses in female Wistar rats given 40 mg/kg, with no effects seen at doses of 0, 10, or 20 mg/kg; there was no evidence of teratogenicity. There was a dose-related increase in the number of resorptions in New Zealand rabbits given doses of 0, 2.5, or 10 mg/kg from day 6 to day 18 of pregnancy, with a corresponding decrease in number of live births; there was no evidence of teratogenicity.
Breast-feeding: It is not known whether Flunarizine is distributed into breast milk in humans; however, it is distributed into the milk of dogs, at concentrations much higher than in plasma.