Flumig Mechanism of Action

Pharmacology: Mechanism of Action: These agents are calcium-ion influx inhibitors (slow-channel blocking agents). Although their mechanism is not completely understood, they are thought to inhibit calcium ion entry through select voltage-sensitive areas termed "slow channels" across cell membranes. By reducing intracellular calcium concentration in cardiac and vascular smooth muscle cells, they dilate coronary arteries and peripheral arteries and arterioles, and may reduce heart rate, decrease myocardial contractility (negative inotropic effect), and slow atrioventricular (AV) nodal conduction.
By inhibiting the vasoconstriction that occurs in the prodromal phase, calcium channel blockade may relieve or prevent reactive vasodilation.
Pharmacokinetics: Absorption: Well absorbed.
Protein binding: Very high (99%).
Half-life: 19 days.
Time to peak concentration: 2 to 4 hours.
Time to peak effect: Multiple doses: Several weeks.
Elimination: Drug and its metabolites: very slow and prolonged.
Biliary/fecal: Less than 6% in the first 48 hours.
Renal: Less than 0.2% in the first 48 hours.