Note: Combination containing any of the following medications, depending on the amount present, may also interact with this medication.
Anesthetics, hydrocarbon inhalation (concurrent use with calcium channel blocking agents may produce additive hypotension; although calcium channel blocking agents may be useful to prevent supraventricular tachycardias, hypertension, or coronary Spasm during surgery, caution is recommended during use).
Non-Steroidal Anti-inflammatory drugs (NSAIDs), especially Indomethacin (Indomethacin, and possibly other NSAIDs, may antagonize the antihypertensive effect of calcium channel blocking agents by inhibiting renal prostaglandin synthesis and/or by causing sodium and fluid retention; the patient should be carefully monitored to confirm that the desired effect is being obtained.
Beta-adrenergic blocking agents, systemic or ophthalmic; Calcium supplements; Carbamazepine; Cyclosporine; Quinidine or Theophylline or Valproate; Cimetidine; Ranitidine and Famotidine do not appear to significantly affect calcium channel blocking agent metabolism; Digitalis; Disopyramide or Flecainide; Erythromycin; Estrogens; Grapefruit juice; Highly protein-bound medications, such as: anticoagulants, Coumarin- and Indandione-derivative anticonvulsants, Hydantoin, anti-inflammatory drugs, nonsteroidal; Quinine; Salicylates Sulfinpyrazone; Hypokalemia-producing medications, such as: parenteral Amphotericin B; Carbonic anhydrase inhibitors; Corticosteroids, glucocorticoid, especially those with significant mineralocorticoid activity; Corticosteroids, mineralocorticoid; Corticotropin (ACTH) Diuretics, potassium-depleting (such as Bumetanide, Ethacrynic acid, Furosemide, Indapamide. Mannitol. or thiazides) Sodium phosphates; Hypotension-producing medications; Lithium; Neuromuscular blocking agents; Phenobarbital; Prazosin, and possibly other alpha-adrenergic blocking agents, Procainamide or Quinidine or Other medications causing Q-T interval prolongation; Rifampin, and possibly other hepatic enzyme inducers; Sympathomimetics; Tacrolimus.
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