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ATC Code: A07F A02.
Pharmacology: Pharmacodynamics: Saccharomyces boulardii is an intestinal replacement flora, which acts as antidiarrheal microorganisms in the digestive tract. Pharmacodynamics of Saccharomyces boulardii, live probiotic yeast, have been established on various models by in vitro and in vivo, animal, and human studies which demonstrated it has: Anti-inflammatory (enterohemorrhagic E. coli); Anti-microbial (enterohemorrhagic E. coli; C. difficile; S. typhimurium; Yersinia enterocolitica; C. albicans; C. krusei; C. pseudotropicalis); Enzymatic (disaccharidases; leucine aminopeptidase; spermine; spermidine); Metabolic; Anti-toxinic (C. diff. toxin A; cholera toxin); And immuno-enhancing (secretory-IgA and immunoglobulins) activities which are beneficial when Saccharomyces boulardii is used to treat diarrhoea of various origins (infectious -viral, bacterial- or not) in humans.
Pharmacokinetics: After repeated oral doses, Saccharomyces boulardii transits in the digestive tract without colonizing it.
Saccharomyces boulardii is no longer present in the stools 2 to 5 days after discontinuation of treatment.
