Fevere Use In Pregnancy & Lactation

Paracetamol is generally considered to be the analgesic of choice in pregnant patients. However, the frequent use of Paracetamol (defined as most days or daily use) in late pregnancy may be associated with an increased risk of persistent wheezing in the infant. The authors emphasized that the number of pregnant women taking frequent doses was very small and they recommended that infrequent Paracetamol should remain the analgesic of choice in pregnancy.
Breast feeding: No adverse effects have been observed in breast-feeding infants whose mothers were receiving Paracetamol, and the American Academy of Pediatrics considers that it is therefore usually compatible with breastfeeding. The British National Formulary also considers that the amount of Paracetamol distributed into breast milk is too small to be harmful to a breast-fed infant.
Pharmacokinetic studies in 12 nursing mothers given a single dose of Paracetamol showed that peak Paracetamol concentrations in breast milk of 10 to 15 micrograms/mL were achieved in 1 to 2 hours. Plasma concentrations were determined in 2 mothers; a breast milk/plasma ratio of about 1 was reported. Similar findings have been reported from other studies.