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Symptoms of overdosage may include nausea, vomiting, abdominal pain, diaphoresis, generalized weakness and lethargy. If an ovedosage of Paracetamol is suspected, blood should be withdrawn immediately for Paracetamol plasma assay, without regards to the presence or absence of symptomology.
Treatment: The acute hepatotoxicity and nephrotoxicity of Paracetamol can be overcome by administration of sulphydryl donors e.g., N-Acetylcysteine which should be given as soon as possible after congestion. Treatment after 12 hours is not effective. Paracetamol overdosage should be treated with gastric lavage if the patient is seen within 24 hours of ingestion of the drug.
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