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Hepatocellular insufficiency, severe renal insufficiency (creatinine clearance (CrCl) ≤30 mL/min), chronic alcoholism, chronic malnutrition (low reserves of hepatic glutathione), dehydration.
Use in lactation: After oral administration, Paracetamol is excreted into breast milk in small quantities. No adverse effects on nursing infants have been reported.
Consequently, Paracetamol may be used in breastfeeding women.
Use in children: No safety and efficacy data are available for premature neonates.
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