Fazef Special Precautions

General: Prolonged use of Cefazolin (Fazef) may result in overgrowth of nonsusceptible organisms. Careful clinical observation of the patient is essential.
When Cefazolin (Fazef) is administered to patients with low urinary output because impaired renal function, lower daily dosage is required (see Dosage & Administration).
As with other beta-lactam antibiotics, seizures may occur if inappropriately high doses are administered to patients with impaired renal function (see Dosage & Administration).
Cefazolin (Fazef) is administered to patients with impaired renal function (see Dosage & Administration).
Cefazolin (Fazef) as with all cephalosporins, should be prescribed with caution in individuals with a history of gastrointestinal disease, particular colitis.
Cephalosporins may be associated with a fall in prothrombin activity. Those at risk include patients with renal or hepatic impairment or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients receiving a protracted course of antimicrobial therapy and patients previously stabilized on anticoagulant therapy. Prothrombin time should be monitored in patients at risk of exogenous vitamin K administered as indicated.
Carcinogenesis/Mutagenesis: Mutagenicity studies a long-term studies in animals to determine the carcinogenic potential of Cefazolin for injection (cefazolin for injection) have not been performed.
Use in Children: Safety and effectiveness for use in premature infants and neonates have not been established. See Dosage and Administration for recommended dosage in pediatric patients over 1 month.
Use in Pregnancy & Lactation: Pregnancy: Teratogenic Effects: Pregnancy and Category B: Reproduction studies have been performed in rats, mice and rabbits at doses up to 25 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to Cefazolin (Fazef). There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Labor and Delivery: When cefazolin has been administered prior to caesarean section, drug levels in cord blood have been approximately one quarter to one third of maternal drug levels. The drug appears to have no adverse effect on the fetus.
Nursing Mothers: Cefazolin (Fazef) is present in very low concentrations in the milk of nursing mothers. Caution should be exercised when Cefazolin (Fazef) is administered to a nursing woman.