Fazef Indications/Uses

Cefazolin (Fazef) is indicated in the treatment of the following serious infections due to susceptible organisms: Respiratory tract infections due to Streptococcus pneumoniae. Klebsiella species, Haemophilus influenzae, Staphylococcus aureus (penicillin-sensitive and penicillin- resistant) and group A beta-hemolytic streptococci. Injectable benzathine penicillin is considered to be the drug choice in treatment and prevention of streptococcal infections, including the prophylaxis of rheumatic fever. Cefazolin (Fazef) is effective in the eradication of streptococci from the nasopharynx; however, data establishing the efficacy of Cefazolin (Fazef) in the subsequent prevention of rheumatic fever are not available at present.
Urinary tract infections due to Escherichia coli, Proteus mirabilis, Klebsiella species and some strains of enterobacter and enterococci.
Skin and skin structure infections due to Staphylococcus aureus (Penicillin-sensitive and penicillin-resistant), group A beta-hemolytic streptococci and other strains of streptococci.
Biliary tract infections due to Escherichia coli, various strains of streptococci, Proteus mirabilis, Klebsiella species and Staphylococcus aureus. Genital infections (i.e., prostatitis, epididymitis) due to Escherichia coli, Proteus mirabilis, Klebsiella species and some strain of enterococci.
Septicemia due to Streptococcus pneumoniae, Staphylococcus aureus (penicillin-sensitive and penicillin resistant), Proteus mirabilis, Escherichia coli, and Klebsiella species.
Endocarditis due to Staphylococcus aureus (penicillin-sensitive and penicillin-resistant) and group A beta-hemolytic streptococci.
Appropriate culture and susceptibility studies should be performed to determine susceptibility of the cause organism to Cefazolin (Fazef).
Perioperative prophylaxis: The prophylactic administration of Cefazolin (Fazef) preoperatively, intraoperatively and postoperatively may reduce the incidence of certain postoperative infections in patients undergoing surgical procedures which are classified as contaminated or potentially contaminated (eg, vaginal hysterectomy, and cholecystectomy in high-risk patients such as those over 70 years of age, with acute cholecystitis, obstructive jaundice or common duct bile stones).
The perioperative use of Cefazolin (Fazef) may also be effective in surgical patients in whom infection at the operative site would present a serious risk (e.g., during open-heart surgery and prosthetic arthroplasty).
The prophylactic administration of Cefazolin (Fazef) should usually be discontinued within 24-hour period after the surgical procedure. In surgery where the occurrence of infection may be particularly devastating (e.g., during open-heart surgery and prosthetic arthroplasty), the prophylactic administration of Cefazolin (Fazef) may be continued for 3 to 5 days following the completion of surgery.
If there are signs of infection, specimens for cultures should be obtained for the identification of the causative organism so that appropriate therapy may be instituted. (See Dosage & Administration.)