Fazef Dosage/Direction for Use

Usual Adult Dosage: See Table 1.

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Perioperative Prophylactic Use: Perioperative Prophylactic Use: To prevent postoperative infection in contaminated or potentially contaminated surgery, recommended doses are: a. 1 g I.V or I.M administered 1/2 hour to 1 hour prior to start the surgery.
b. For lengthy operative procedures (e.g., 2 hours or more). 500 mg to 1g I.V or I.M during surgery (administration modified depending on the duration of the operative procedure).
c. 500 mg to 1 gram I.V or I.M every 6 to 8 hours for 24 hours postoperatively. It is important that (1) the preoperative dose be given just (1/2 to 1 hour) prior to start the surgery so that adequate antibiotic levels are present in the serum and tissues at the time of initial surgical incision; and (2) Cefazolin (Fazef) be administered, if necessary, at appropriate intervals during surgery to provide sufficient levels of the antibiotic at the anticipated moments of greatest exposure to infective organisms.
In surgery where the occurrence of infection may be particularly devastating (e.g., open-heart surgery and prosthetic arthroplasty), the prophylactic administration of Cefazolin (Fazef) may be continued for 3 to 5 days following the completion of surgery.
Dosage Adjustment for Patients with Reduced Renal Function: Cefazolin (Fazef) may be used in patients with reduced renal function with the following dosage adjustments: Patients with a creatinine clearance of 55 mL/min or greater or a serum creatinine of 1.5 mg % or less can be given full doses. Patients with creatinine clearance rates of 35 to 54 ml/ min. or serum creatinine of 1.6 to 3.0 mg % can also be given full doses but dosage should be restricted to at least 8-hours intervals. Patients with creatinine clearance rates of 11 to 34 mL/min. or serum creatinine of 3.1 to 4.5 mg % should be given ½ the usual dose every 12 hours. Patients with creatinine clearance rates of 10 mL/min. or serum creatinine clearance rates of 10 mL/min. or less or serum creatinine of 4.6 mg % or greater should be given ½ the usual dose every 18 to 24 hours. All reduced dosage recommendations apply after an initial loading dose appropriate to the severity of the infection. Patients undergoing peritoneal dialysis (see Pharmacology under Actions).
Pediatric Dosage: In pediatric patients a total daily dosage of 25 to 50 mg per kg approximately 10 to 20 mg per pound) of body weight, divided into three or four equal doses, is effective for most mild to moderately severe infections. Total daily dosage may be increased to 100 mg per kg (45 mg per pound) of body weight for severe infections. Since safety for use in premature infants and in neonates has not been established, the use of Cefazolin (Fazef) in these patients is not recommended. (See Table 2 & 3.)

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In pediatric patients with mild to moderate renal impairment (creatinine clearance of 70 to 40 mL/min), 60% of the normal daily dose given in equally divided doses every 12 hours should be sufficient. In patients with moderate impairment (creatinine clearance of 40 to 20 mL/min), 25% of normal daily dose given in equally divided doses every 12 hours should be adequate. Pediatric patients with severe renal impairment (creatinine clearance of 20 to 5 mL/min) maybe given 10% of the normal daily dose every 24 hours. All dosage recommendations apply after an initial loading dose.
Method of Administration: Intramuscular Administration: Reconstitute vials with Sterile Water for Injection according to the dilution table under Cautions for Usage. Shake well until dissolved. Cefazolin (Fazef) should be injected into large muscle mass. Pain on injection is infrequent with Cefazolin (Fazef).
Intravenous Administration: Direct (bolus) Injection: Following reconstitution according to the dilution table under Cautions for Usage, further dilute vials with approximately 5 mL Sterile Water for Injection. Inject the solution slowly over 3 to 5 minutes, directly or through tubing for patients receiving parenteral fluids.