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Pregnancy: Category D. do not use tetracycline during pregnancy. Tetracyclines readily cross the placenta, are found in fetal tissues and can have toxic effects on the developing fetus (retardation of skeletal development). Evidence of embryotoxicity has also been noted in animals treated early in pregnancy.
Lactation: Tetracyclines are excreted in breast milk. A dosage of 2 g/day for 3 days has achieved a milk plasma ratio of 0.6 to 0.8.
Because of potential adverse reactions, decide whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Pediatric Use: Do not use in children aged 8 years and below because of the effect of tetracyclines in teeth (permanent discoloration and possibly enamel hypoplasia) and bone.
