Doxin Adverse Reactions

Due to oral Doxycycline's virtually complete absorption, side effects of the lower bowel, particularly diarrhea, have been infrequent.
The following reactions have been observed with tetracyclines: Gastrointestinal: Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region. Rarely, hepatotoxicity, esophagitis and esophageal ulcerations.
Skin: Maculopapular and erythematous rashes; exfoliative dermatitis (uncommon).
Renal: Rise in BUN (dose-related).
Hypersensitivity reactions: Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis and exacerbation of systemic lupus erythematosus.
Blood: Hemolytic anemia, thrombocytopenia, neutropenia and eosinophilia.
Others: Bulging fontanels in infants and intracranial hypertension in adults.
when given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of the thyroid gland. No abnormalities of thyroid function studies are known to occur.