Doxin Special Precautions

Benign intracranial hypertension manifested as headache and blurred vision has been reported in adults receiving tetracyclines. Bulging fontanels have been associated with tetracycline use in infants. While both conditions and related symptoms usually resolve on tetracycline discontinuation, possibility for permanent sequelae exists.
As with other antibiotic preparations, use of doxycycline may result in overgrowth of nonsusceptible organisms, including fungi. Discontinue antibiotic if superinfection occurs and institute appropriate therapy.
Laboratory tests: In venereal disease, when co-existent syphilis is suspected, perform dark field examinations before treatment is started and repeat blood serology monthly for at least 4 months.
Perform laboratory evaluation of organ systems, including hematopoietic, renal and hepatic studies in long-term therapy.
Expired products: Do not administer expired tetracyclines under any circumstance. Its degradation products are highly nephrotoxic and have on occasion, produced a Fanconi-like syndrome.