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Signs and Symptoms: Loperamide: Loperamide overdose may result in constipation, central nervous system (CNS) depression (e.g., near unconsciousness, coordination abnormality, drowsiness, constriction of the pupil of the eye, muscle stiffness, respiratory depression), urinary retention, and paralytic ileus (obstruction of the intestine due to paralysis of the intestinal muscles). Patients with liver problems and children may be more sensitive to CNS effects.
Cardiac events such as QT interval prolongation, torsades de pointes/other serious ventricular arrhythmias (life-threatening irregular heartbeat), cardiac arrest (stopping of heartbeat), and syncope (fainting/temporary loss of consciousness) have been observed following loperamide overdose. Fatal cases have been also reported.
Reported overdosage within 24 hours resulted in nausea after 40 mg (20 capsules) and vomiting after 60 mg (30 capsules).
Simeticone: There have been no cases of overdosage reported with simeticone use. If overdosage is suspected, consult a doctor immediately.
What to do when the patient has taken more than the recommended dosage: If the patient has taken more than the recommended dosage (i.e., more than 4 capsules per day), consult a doctor or contact a poison control center right away. Quick medical attention is important even if the patient do not notice any signs or symptoms.
Children may react more strongly to large amounts of loperamide + simeticone than adults.
If a child takes too much or shows any of the previously mentioned symptoms, call a doctor immediately.
