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Caution administration: Patients with severe liver disorder; Patients with moderate or severe renal disorder; Patients with a history of hypersensitivity to penicillin or cephalosporin; Patients who have a predisposition to develop allergic reactions such as bronchial asthma, rash and urticaria; Patients with poor oral intake or receiving parenteral nutrition or aged patients (as vitamin K deficiency symptoms may appear, close observation should be made).
General precaution: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions or vascular neurological edema have been reported in patients on penicillin therapy. These reactions are more likely occur in individuals with a history of penicillin hypersensitivity or a history of sensitivity multiple allergens and more commonly occur during therapy with non-oral than oral.
As non-sensitive bacteria's overgrowth can occur sometimes in patients with prolonged treatment, carefully observe in case of over 14 days administration.
The change at liver function examination in some patients receiving this drug is reported. Clinical significance is uncertain but patients with hepatic dysfunction sign should use it with caution. Severe or generally reversible bile stasis jaundice is reported rarely. Any symptoms or signs cannot be revealed in 6 weeks after therapy has been discontinued.
This drug's dosage should be adjusted according to age and administration in patients with moderate or severe renal disorder.
As erythema eruption is associated with glandular fever due to amoxicillin use, carefully administer.
