Cobiomax Drug Interactions

Co-Administration of Probenecid cannot be recommended. Probenecid decreases the renal tubular secretion of Amoxicillin and may result in increased and prolonged blood levels of amoxicillin. It is not related with clavulanic acid.
The concurrent administration of allopurinol and ampicillin increases substantially the incidence of rashes in patients receiving both drugs as compared to patients receiving alone. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients.
Do not co-administer with disulfiram.
Increased bleeding time and prothrombin time in patients receiving this drug have been reported so, Co-Amoxiclav (COBIOMAX) should be used with cautions in patients with anticoagulant therapy.
Notice patient that this drug may reduce the efficacy of oral contraceptives.
Interference with Laboratory Test: Oral administration of Co-Amoxiclav (COBIOMAX) will result in high urine concentrations of amoxicillin, High urine concentrations of ampicillin may result in false-positive reactions when testing for the glucose in urine using Clinitest, Benedict's solution or Fehling's Solution.