Cefovex Dosage/Direction for Use

Cefoxitin is given as the sodium salt by deep intramuscular injection, by slow intravenous injection over 3 to 5 minutes, or by intermittent or continuous intravenous infusion.
Doses are expressed in terms of the equivalent amount of cefoxitin. 1.05 g of cefoxitin sodium is approximately equivalent to 1 g of cefoxitin.
The usual adult dose: 1 or 2 g every 8 hours although it may be given more frequently (every 4 or 6 hours). In severe infections: up to 12 g daily has been recommended.
Children and neonates: may be given 20 to 40 mg/kg, every 12 hours for neonates up to 1 week old, every 8 hours for those aged 1 to 4 weeks, and every 6 to 8 hours for older infants and children; in severe infections, up to 200 mg/kg daily may be given, to a maximum of 12 g daily.
For the treatment of uncomplicated urinary-tract infections, cefoxitin 1 g twice daily has been given intramuscularly.
For the treatment of uncomplicated gonorrhoea, a single dose of 2 g intramuscularly has been given with probenecid 1 g by mouth.
For surgical infection prophylaxis, the usual adult dose is cefoxitin 2 g intramuscularly or intravenously 30 to 60 minutes prior to the procedure and then every 6 hours, not usually for more than 24 hours. Infants and children undergoing surgical procedures can be given doses of 30 to 40 mg/kg, at the same time intervals as adults; neonates may be given 30 to 40 mg/kg, but at intervals of 8 to 12 hours.
At caesarean section a single 2-g dose may be given intravenously to the mother as soon as the umbilical cord is clamped. If necessary, a 3-dose regimen, with further 2-g doses 4 and 8 hours after the initial dose, may be used.
Dosage in renal impairment: In renal impairment, dosage of cefoxitin should be reduced according to creatinine clearance (CC). In adults, after an initial loading dose of 1 to 2 g, maintenance doses are: CC 30 to 50 mL/minute: 1 to 2 g every 8 to 12 hours.
CC 10 to 29 mL/minute: 1 to 2 g every 12 to 24 hours.
CC 5 to 9 mL/minute: 500 mg to 1 g every 12 to 24 hours.
CC below 5 mL/minute: 500 mg to 1 g every 24 to 48 hours.
In patients undergoing haemodialysis, the loading dose should be repeated after each dialysis session.