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Cetirizine hydrochloride (Benadryl One) is a piperazine derivative and a metabolite of hydroxyzine. It competes reversibly with histamine to block the histamine (H1) receptor sites. Cetirizine hydrochloride is considered a long-acting non-sedating antihistamine and has some mast-cell stabilizing activity.
Cetirizine hydrochloride (Benadryl One) is a long-acting anti-histamine causing little or no drowsiness. It does not demonstrate any antimuscarinic activity. This drug competes reversibly with histamines which are released from mast cells. Once bound to H1 receptor sites in the tissues, cetirizine hydrochloride inhibits histamine-induced allergic reactions by blocking eosinophil infiltration to the site of allergen-induced cutaneous reactions.
