Aprovasc Overdosage

Manifestations and Management of Overdose or Accidental Ingestion: Experience with adults exposed to Irbesartan doses up to 900 mg/day for 8 weeks did not reveal toxicity. No specific information is available about the treatment of overdosage with irbesartan. The information available on the overdose of amlodipine suggests that it could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension and shock with fatal prognosis have been reported. Close monitoring of patient should be done and treatment should be symptomatic and supportive.
Suggested measures include gastric lavage. The administration of activated carbon to healthy individuals immediately or up to two hours after the ingestion of 10 mg of amlodipine has shown a significant decrease in the absorption of amlodipine.
As amlodipine is highly protein bound and irbesartan is not removed from the body with hemodialysis, hemodialysis does not seem to offer any benefit.
If massive overdose occurs, initiate active cardiorespiratory monitoring. Frequent measurement of blood pressure is essential. Clinically significant hypotension due to amlodipine overdose requires active cardiovascular support including limb elevation and monitoring of circulating volume and urinary output. A vasoconstrictor can help restore vascular tone and blood pressure, when there is no contraindication to its use.
Intravenous calcium gluconate may be of benefit in reversing the effects of calcium channel blockade.