Aprovasc Dosage/Direction for Use

General: The recommended dosage of Irbesartan/Amlodipine (Aprovasc) is one tablet per day.
Irbesartan/Amlodipine (Aprovasc) should be administered in patients whose blood pressure is not adequately controlled on monotherapy with irbesartan or amlodipine or for continuation of therapy for patients receiving irbesartan and amlodipine as separate tablets. Dose should be individualized based on response to the therapy with individual components and antihypertensive response required. The maximum recommended dose with Irbesartan/Amlodipine (Aprovasc) is 300 mg/10 mg per day.
Special Populations: Children: The safety and efficacy of Irbesartan/Amlodipine (Aprovasc) has not been established in this population.
Elderly: No dosage adjustment for Irbesartan/Amlodipine (Aprovasc) is necessary in the elderly. (See Pharmacology: Pharmacokinetics under Actions.)
Hepatic impairment: Due to the presence of amlodipine, Irbesartan/Amlodipine (Aprovasc) should be administered with caution in patients with hepatic insufficiency. (See Warnings and Pharmacology: Pharmacokinetics under Actions.)
Renal impairment: No dosage adjustment for Irbesartan/Amlodipine (Aprovasc) is necessary in patients with impaired renal function.
Administration: Irbesartan/Amlodipine (Aprovasc) can be used with or without food.