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Anastrozole inhibited cytochrome P450 1A2, 2C8/9 and 3A4 in vitro, but a clinical interaction study with warfarin indicated that Anastrozole at a 1 mg dose does not significantly inhibit the metabolism of substances that are metabolised via cytochrome P450.
No clinically significant interactions between Anastrozole and bisphosphonates have been identified.
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