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Anastrozole is contraindicated in: premenopausal women; pregnant or lactating women; patients with severe renal impairment (creatinine clearance less than 20 mL/min); patients with moderate or severe hepatic disease; patients with known hypersensitivity to Anastrozole or to any of the excipients.
Oestrogen-containing therapies should not be co-administered with Anastrozole as they would negate its pharmacological action.
Tamoxifen should not be co-administered with Anastrozole, as this may diminish its pharmacological action.
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