Amlife Overdosage

Losartan potassium: There is limited data on overdosage with losartan in humans. Losartan overdose will most likely manifest as hypotension and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation.
Institute symptomatic treatment and monitor vital signs if symptomatic hypotension occurs. Measures are depending on the time of drug intake and kind and severity of symptoms. Stabilization of the cardiovascular system should be given priority. After oral intake, the administration of a sufficient dose of activated charcoal is indicated. Close monitoring of the vital parameters should be performed. Vital parameters should be corrected if necessary.
Losartan and its metabolite are not removed by hemodialysis.
Amlodipine besilate: Overdosage might be expected to cause excessive peripheral vasodilation with marked hypotension and possibly a reflex tachycardia.
Institute active cardiac and respiratory monitoring during massive overdose. Frequent blood pressure measurements are necessary. Initiate cardiovascular support (i.e., elevation of extremities, judicious administration of fluids) if hypotension occurs. If hypotension remains unresponsive to these conservative measures, administration of vasopressors such as phenylephrine should be considered with attention to circulation volume and urine output. Intravenous calcium gluconate may help reverse the effects of calcium entry blockade. Hemodialysis is not likely to be of benefit since amlodipine is highly protein bound.