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Hypersensitivity to losartan potassium, amlodipine besilate, or to any component of the product.
Women who are pregnant, trying to get pregnant or suspect that they are pregnant, or breastfeeding mothers.
Severe hepatic impairment.
Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m2).
Severe hypotension.
Shock (including cardiogenic shock).
Obstruction of the outflow tract of the left ventricle (e.g., high grade aortic stenosis).
Hemodynamically unstable heart failure after myocardial infarction.
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