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Dose should be lowered (5 mg daily or 10 mg every other day) in patients with liver impairment or renal impairment (GFR <30 mL/min). It should also be used with caution in patients with prostatic hyperthrophy, urinary retention, glaucoma and epilepsy. Children and elderly are more susceptible to side effects.
Safety and efficacy of loratadine in children younger than 2 years of age have not yet been established.
Drug known to inhibit hepatic metabolism should be coadministered with caution until definitive interaction studies can be completed.
Effects on Ability to Drive and Use Machines: In clinical trials that assessed driving ability, no impairment occurred in patients receiving loratadine. However, patients should be informed that very rarely some people experience drowsiness, which may affect their ability to drive or use machines.
