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In adults, somnolence, tachycardia and headache have been reported with doses greater than 10 mg (40-180 mg). In children, extrapyramidal side effects and palpitations have been reported in doses greater than 10 mg.
General symptomatic and supportive measures should be instituted in the event of overdosage. The treatment should consist of emesis, preferably by administration of ipecac syrup except in patients with impaired consciousness. Following emesis, activated charcoal should be administered to absorb any remaining drug. However, if emesis is unsuccessful or contraindicated, gastric lavage should be performed using normal saline. Saline cathartics may be of value as it draw water into the bowel by osmosis, hence rapidly diluting the bowel content. Hemodialysis is of no value as loratadine is not eliminated by hemodialysis.
