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Loratadine has no potentiating effect when administered concurrently with alcohol. Increase in plasma concentrations of loratadine has been reported with concomitant use of ketoconazole, erythromycin or cimetidine in healthy individuals but without clinically significant changes. Caution should be exercised when coadministering drugs known to inhibit hepatic metabolism.
Drug/lab test: Loratadine should be discontinued approximately 48 hours prior to skin testing procedures. Since antihistamines may prevent or diminish otherwise positive reactions to dermal reactivity indicators.
