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Postural Hypotension/Syncope: As with all alpha-blockers, a very small percentage of patients have experience postural hypotension evidenced by dizziness and weakness, or rarely loss of consciousness (syncope), particularly with the commencement of therapy. When instituting therapy with any effective alpha-blocker, the patient should be advised how to avoid symptoms resulting from postural hypotension and what measures to take should they develop. The patient should be cautioned to avoid situations where injury could result, should dizziness or weakness occur during the initiation of Pencor therapy.
Use with PDE-5 Inhibitors: Concomitant administration of an alpha-blocker with a PDE-5 inhibitor should be used with caution as it may lead to symptomatic hypotension in some patients.
Impaired liver function: As with any drug wholly metabolized by the liver, Pencor should be administered with caution to patients with evidence of impaired hepatic function.
