Pencor Overdosage

Symptoms: Circulatory failure.
Treatment: Place the patient in the supine position and elevating the legs is most important; if shock is present, additional measures are necessary. Volume expanders may be used to treat shock, followed by administration of vasopressor. Symptomatic, supportive treatment and monitoring of fluid and electrolyte status.
Experience with Pencor overdosage is limited. Two adolescents who each intentionally ingested 40 mg Pencor with Diclofenac or Paracetamol, were treated with gastric lavage with activated charcoal and made full recoveries. A two-year-old child who accidentally ingested 4 mg Pencor was treated with gastric lavage and remained normotensive during the five-hour emergency room observation period. A six-month-old child accidentally received a crushed 1 mg tablet of Pencor and was reported to have been drowsy. A 32-year-old female with chronic renal failure, epilepsy and depression intentionally ingested 60 mg Pencor (blood level 0.9 μg/mL; normal values in hypertensives = 0.02 μg/mL); death was attributed to a grand mal seizure resulting from hypotension which responded to fluid therapy. The oral LD₅₀ of Doxasozin is greater than 1,000 mg/Kg in mice and rats. The most likely manifestation of overdosage would be hypotension, for which the usual treatment would be intravenous infusion of fluid. As Doxazosin is highly protein bound, dialysis would not be indicated