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Overdose and Treatment: In the event of overdosage, hypernatraemia or hyperkalaemia could occur.
Hypernatraemia requires the use of sodium-free fluids and the cessation of excessive sodium intake. Very occasionally, dialysis has been needed in severe hypernatraemia.
Iso-osmotic overload is managed by sodium and water restrictions plus measures to increase renal sodium and water loss such as 'loop diuretics' (e.g. frusemide) or, in specific circumstances, antimineralcorticoid agents.
Mild hyperkalaemia may be treated with sodium polystyrene sulphonate, administered by mouth or as an enema. In severe hyperkalaemia, treatment with haemodialysis or peritoneal dialysis may become necessary.
Hyperkalaemia associated with hyponatraemia may respond to treatment with infusions of sodium salts.
