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As with other cephalosporins, anaphylactic shock cannot be ruled out even if a thorough patient history is taken. Anaphylactic shock requires immediate countermeasures such as intravenous epinephrine followed by a glucocorticoid. Pseudomembranous colitis has been reported with nearly all antibacterial agents, including ceftriaxone.
Therefore, it is important to consider this diagnosis in patients with diarrhea subsequent to the administration of antibacterial agents. Superinfections with nonsusceptible microorganisms may occur with other antibacterial agents. Shadows which have been mistaken for gallstones have been detected on sonograms of the gallbladder, usually following doses higher than the standard recommended dose. These shadows are, however, precipitates of calcium ceftriaxone which disappear on completion or discontinuation of CEFTREX therapy. Rarely have these findings been associated with symptoms. In symptomatic cases, conservative non-surgical management is recommended. Discontinuation of treatment in symptomatic cases should be at the discretion of the physician.
Use in Pregnancy & Lactation: See USE IN PREGNANCY & LACTATION section for further information.
Use in Children: Safety and effectiveness of CEFTREX in neonates, infants and children have been established for the dosages described in the Dosage & Administration.
In vitro studies have shown that ceftriaxone, like some other cephalosporins, can displace bilirubin from serum albumin. CEFTREX should not be administered to hyperbilirubinemic neonates, especially prematures.
