Adult & childn >12 yr 1-2 g once daily. Severe infections Max: 4 g once daily. Infant & childn 3 wk-12 yr 20-80 mg/kg once daily. Neonate up to 2 wk 20-50 mg/kg once daily. Max: 50 mg/kg daily. Bacterial meningitis Infant & childn Initially 100 mg/kg once daily. Max: 4 g daily. Gonorrhea 250 mg IM as single dose. Preterminal renal failure (CrCl <10 mL/min) Max: 2 g daily.
Discontinue use if allergic reactions occur. Hypersensitivity to penicillins, cephalosporins, carbapenems or other β-lactams. Anaphylactic shock. Pseudomembranous colitis; superinfections w/ nonsusceptible microorganisms. Shadows on gallbladder sonogram due to high dose. Not to be administered w/ Ca-containing IV soln. Severe renal & hepatic impairment. Not to be used during 1st trimester of pregnancy. Lactation. Not to be used in hyperbilirubinemic neonates especially prematures.
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