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Manifestation of Alprazolam overdosage include somnolence, confusion, impaired coordination, slurred speech, respiratory depression, diminished reflexes, and coma. Death has been reported in association with overdoses of Alprazolam by itself, as it has with other Benzodiazepines. In addition, fatalities have been reported in patients who have overdosed with a combination of a single Benzodiazepine, including Alprazolam, and alcohol; alcohol levels seen in some of these patients have been lower than those usually associated with alcohol-induced fatality.
Treatment of overdosage is primarily supportive of respiratory and cardiovascular function. The value of dialysis has not been determined. Flumazenil may be used as an adjunct to the management of respiratory and cardiovascular function associated with overdose.
