Pharmacology: Alprazolam is an effective anxiolytic, antidepressant, and antipanic agent. Because of its similarity to other Benzodiazepines, it is assumed that Alprazolam undergoes transplacental passage, and that it is excreted in human milk. Alprazolam and its metabolites are excreted primarily in the urine. The predominant metabolites are alpha-hydroxy-alprazolam, 4-hydroxy Alprazolam, and a Benzophenone derived from Alprazolam. The biological activity of alpha-hydroxy-alprazolam is approximately one-half that of Alprazolam. The Benzophenone metabolite is essentially inactive.
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