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Uperio

Uperio Overdosage

sacubitril + valsartan

Manufacturer:

Novartis Indonesia
Full Prescribing Info
Overdosage
Limited data are available with regards to overdosage in human subjects with UPERIO. In healthy volunteers, a single dose of UPERIO 1200 mg, and 900 mg multiple doses (14 days) have been studied and were well tolerated.
Hypotension is the most likely symptom of overdosage due to the blood pressure lowering effects of UPERIO. Symptomatic treatment should be provided.
UPERIO is unlikely to be removed by hemodialysis due to high protein binding.
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