Uperio Description

UPERIO 50 mg film-coated tablets: Each film-coated tablet contains 24.3 mg sacubitril and 25.7 mg valsartan (as Sacubitril valsartan sodium hydrate).
UPERIO 100 mg film-coated tablets: Each film-coated tablet contains 48.6 mg sacubitril and 51.4 mg valsartan (as Sacubitril valsartan sodium hydrate).
UPERIO 200 mg film-coated tablets: Each film-coated tablet contains 97.2 mg sacubitril and 102.8 mg valsartan (as Sacubitril valsartan sodium hydrate).
Sacubitril valsartan sodium hydrate. UPERIO contains a salt complex of the anionic forms of sacubitril and valsartan, sodium cations, and water molecules in the molar ratio of 1:1:3:2.5 respectively. Following oral administration, UPERIO dissociates into sacubitril (which is further metabolized to LBQ657 [sacubitrilat]) and valsartan.
Excipients/Inactive Ingredients: Microcrystalline cellulose, low-substituted hydroxypropylcellulose, crospovidone, magnesium stearate (vegetable origin), talc and colloidal silicon dioxide.
Excipients of film coating: hypromellose, titanium dioxide (E 171), Macrogol 4000, talc, iron oxide red (E 172).
For 50 and 200 mg: iron oxide black (E 172). For 100 mg: iron oxide yellow (E 172).