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Hypersensitivity to the active substance or to any of the excipients.
Concomitant use with ACE inhibitors (see Precautions, Dosage & Administration, and Interactions). UPERIO must not be administered until 36 hours after discontinuing ACE inhibitor therapy.
Known history of angioedema related to previous ACE inhibitor or ARB therapy.
Hereditary or idiopathic angiodema (see Precautions).
Concomitant use with aliskiren in patients with Type 2 diabetes or in patients with renal impairment (eGFR <60 ml/min/1.73 m2) (see Precautions, and Interactions).
Severe hepatic impairment, biliary cirrhosis and cholestasis.
Pregnancy. (see Use in Pregnancy & Lactation).
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