Pharmalene Special Precautions

If patients use cosmetics, these should be a non-comedogenic and non-astringent.
Moisturizers may be used if necessary, however, products containing Alpha hydroxy or Glycolic acids should be avoided.
Depending upon the severity of side effects, patients should be instructed to reduce the frequency of application or discontinue use.
If a reaction suggesting sensitivity or chemical irritation occurs, use of the medication should be discontinued.
Exposure to sunlight, including sunlamps, should be minimized during the use of Adapalene.
Patients who normally experience high levels of sun exposure, and those with inherent sensitivity to sun, should be warned to exercise caution.
Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided.
Weather extremes, such as wind or cold, also may be irritating to patients under treatment with Adapalene.
Avoid contact with eyes, lips, angles of the nose, and mucous membranes.
Exposure of the eye this medication may result in reactions such as swelling, conjunctivitis, and eye irritation.
The product should not be applied to cuts, abrasions, eczematous, or sunburned skin, nor should it be used in patients with severe acne, or acne involving large areas of the body.
Wax epilation should not be performed on treated skin due to the potential for skin erosions.
Adapalene did not exhibit mutagenic and genotoxic effects.
In the oral study, increased incidence of benign and malignant pheochromocytomas in the adrenal modulas of male rats was observed.
Because of the risk of teratogenicity shown in animal studies and since there is no informations on the use of Adapalene in pregnant women, it should not be used in woman of childbearing age unless they are using an effective means of contraception.
This product should not be used during pregnancy, unless considered essential by the physician.
The preparation should be used with caution in nursing mothers.
Safety and effectiveness in pediatric below the age of 12 years have not been established.