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Pharmacology: The chemical name of Adapalene is 6-[3-(1-Adamantyl)-4-Methoxyphenyl]-2-Naphthoic Acid. Adapalene is a chemically stable compound with Retinoid-like pharmacological activity. Biochemical and pharmacological profile studies have demonstrated that Adapalene is a potent modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris.
Mechanistically, Adapalene binds to specific Retinoid acid nuclear receptors but does not bind to the cytosolic receptor protein. Although the exact mode of action of Adapalene is unknown, it is indicated that topical Adapalene normalizes the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.
Pharmacokinetics: Adsorption of Adapalene through human skin is low. Excretion is primarily by the biliary route.
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